Analysis of MMP2 promoter polymorphisms in childhood obesity
1 Discipline of Nutrition, FMHS, The University of Auckland, New Zealand
2 Nutrigenomics New Zealand, New Zealand
3 Department of Paediatrics, FMHS, The University of Auckland, New Zealand
BMC Research Notes 2011, 4:253 doi:10.1186/1756-0500-4-253Published: 21 July 2011
Several lines of evidence suggest a possible functional role of Matrix metalloproteinase -2 (MMP-2) in obesity. The aim of this study was to evaluate the role of MMP-2 promoter polymorphisms in percentage body fat (PBF) as a measure of childhood obesity in a New Zealand population.
546 samples from the Auckland Birthweight Collaborative (ABC) study were genotyped for the three MMP-2 promoter SNPs -1306 C/T (rs243865), -1575G/A (rs243866) and -790 T/G (rs243864) using the Sequenom genotyping platform. The results demonstrated that an MMP-2 promoter haplotype is associated with PBF in New Zealand 7 year old children.
We have previously determined that environmental factors are associated with differences in PBF in this study group, and now we have demonstrated a possible genetic contribution.