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Open Access Short Report

Analysis of MMP2 promoter polymorphisms in childhood obesity

Angharad R Morgan12*, Dug Yeo Han12, John MD Thompson3, Edwin A Mitchell3 and Lynnette R Ferguson12

Author Affiliations

1 Discipline of Nutrition, FMHS, The University of Auckland, New Zealand

2 Nutrigenomics New Zealand, New Zealand

3 Department of Paediatrics, FMHS, The University of Auckland, New Zealand

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BMC Research Notes 2011, 4:253  doi:10.1186/1756-0500-4-253

Published: 21 July 2011

Abstract

Background

Several lines of evidence suggest a possible functional role of Matrix metalloproteinase -2 (MMP-2) in obesity. The aim of this study was to evaluate the role of MMP-2 promoter polymorphisms in percentage body fat (PBF) as a measure of childhood obesity in a New Zealand population.

Findings

546 samples from the Auckland Birthweight Collaborative (ABC) study were genotyped for the three MMP-2 promoter SNPs -1306 C/T (rs243865), -1575G/A (rs243866) and -790 T/G (rs243864) using the Sequenom genotyping platform. The results demonstrated that an MMP-2 promoter haplotype is associated with PBF in New Zealand 7 year old children.

Conclusion

We have previously determined that environmental factors are associated with differences in PBF in this study group, and now we have demonstrated a possible genetic contribution.

Keywords:
childhood obesity; percentage body fat; matrix metalloproteinase-2; genetic association