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Open Access Research article

Is there an ideal way to initiate antiplatelet therapy with aspirin? A crossover study on healthy volunteers evaluating different dosing schemes with whole blood aggregometry

Saskia H Meves1*, Horst Neubauer2, Ursula Overbeck1 and Heinz G Endres3

Author Affiliations

1 Ruhr University Bochum, Department of Neurology, St. Josef - Hospital, Gudrunstrasse 56, D-44791 Bochum, Germany

2 Ruhr University Bochum, Cardiovascular Center, St. Josef - Hospital, Gudrunstrasse 56, D-44791 Bochum, Germany

3 Ruhr University Bochum, D-44780 Bochum, Germany

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BMC Research Notes 2011, 4:106  doi:10.1186/1756-0500-4-106

Published: 5 April 2011

Abstract

Background

Guidelines recommend an early initiation of aspirin treatment in patients with acute cerebral ischemia. Comparative studies on the best starting dose for initiating aspirin therapy to achieve a rapid antiplatelet effect do not exist. This study evaluated the platelet inhibitory effect in healthy volunteers by using three different aspirin loading doses to gain a model for initiating antiplatelet treatment in acute strokes patients.

Methods

Using whole blood aggregometry, this study with a prospective, uncontrolled, open, crossover design examined 12 healthy volunteers treated with three different aspirin loading doses: intravenous 500 mg aspirin, oral 500 mg aspirin, and a course of 200 mg aspirin on two subsequent days followed by a five-day course of 100 mg aspirin. Aspirin low response was defined as change of impedance exceeding 0 Ω after stimulation with arachidonic acid.

Results

Sufficient antiplatelet effectiveness was gained within 30 seconds when intravenous 500 mg aspirin was used. The mean time until antiplatelet effect was 74 minutes for 500 mg aspirin taken orally and 662 minutes (11.2 hours) for the dose scheme with 200 mg aspirin with a high inter- and intraindividual variability in those two regimes. Platelet aggregation returned to the baseline range during the wash-out phase within 4 days.

Conclusion

Our study reveals that the antiplatelet effect differs significantly between the three different aspirin starting dosages with a high inter- and intraindividual variability of antiplatelet response in our healthy volunteers. To ensure an early platelet inhibitory effect in acute stroke patients, it could be advantageous to initiate the therapy with an intravenous loading dose of 500 mg aspirin. However, clinical outcome studies must still define the best way to initiate antiplatelet treatment with aspirin.

Keywords:
Aspirin; Stroke; Loading Dose; Pharmacokinetics; Aggregometry