Open Access Short Report

Adiponectin levels in people with Latent Autoimmune Diabetes-a case control study

Sinead Brophy1*, Helen Davies2, Jeffrey W Stephens2, Sarah L Prior2, Mark Atkinson2, Stephen Bain2 and Rhys Williams2

Author Affiliations

1 Senior Lecturer in Epidemiology and Public Health. College of Medicine, Swansea University. Swansea, SA2 8PP UK

2 College of Medicine, Swansea University, Swansea, SA2 8PP UK

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BMC Research Notes 2010, 3:317  doi:10.1186/1756-0500-3-317

Published: 22 November 2010

Abstract

Background

To examine adiponectin levels in people with Latent Autoimmune Diabetes in Adults using a matched pair case control study.

Findings

Patients with LADA (n = 64), were matched for sex with type 2 diabetic and non-diabetic controls. A matched paired T-test was used to examine average adiponectin levels in the LADA patients' versus controls. The average adiponectin level for the LADA patients was 9.96 μg/ml compared to 6.4 μg/ml for Type 2 matched controls and 9.6 μg/ml for non-diabetic controls. Mean difference for the LADA-type 2 comparison was calculated after data was log transformed and showed a difference of 1.58 μg/ml (95%CI: 1.28-1.95, p = 0.0001). There was no significant difference between LADA and non-diabetic controls (p = 0.54).

Conclusions

Adiponectin levels are higher among people with LADA compared to those with type 2 diabetes and are equivalent to levels seen in non-diabetic controls. This suggests that risk of complications in LADA, as with type 1 diabetes may be related more to glycaemic control rather than to factors of the metabolic syndrome.