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Open Access Highly Accessed Technical Note

EasyModeller: A graphical interface to MODELLER

Bhusan K Kuntal, Polamarasetty Aparoy and Pallu Reddanna*

Author Affiliations

School of Life Sciences, University of Hyderabad, Hyderabad 500 046, India

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BMC Research Notes 2010, 3:226  doi:10.1186/1756-0500-3-226

Published: 16 August 2010



MODELLER is a program for automated protein Homology Modeling. It is one of the most widely used tool for homology or comparative modeling of protein three-dimensional structures, but most users find it a bit difficult to start with MODELLER as it is command line based and requires knowledge of basic Python scripting to use it efficiently.


The study was designed with an aim to develop of "EasyModeller" tool as a frontend graphical interface to MODELLER using Perl/Tk, which can be used as a standalone tool in windows platform with MODELLER and Python preinstalled. It helps inexperienced users to perform modeling, assessment, visualization, and optimization of protein models in a simple and straightforward way.


EasyModeller provides a graphical straight forward interface and functions as a stand-alone tool which can be used in a standard personal computer with Microsoft Windows as the operating system.