Open Access Short Report

NOD2-C2 - a novel NOD2 isoform activating NF-κB in a muramyl dipeptide-independent manner

Marcel Kramer1*, Janne Boeck3, Daniela Reichenbach2, Christoph Kaether2, Stefan Schreiber3, Matthias Platzer1, Philip Rosenstiel3 and Klaus Huse1

Author Affiliations

1 Genome Analysis, Leibniz Institute for Age Research - Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany

2 Membrane Trafficking, Leibniz Institute for Age Research - Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany

3 Institute of Clinical Molecular Biology, University Hospital Schleswig-Holstein, Christian Albrechts University, Schittenhelmstrasse 12, 24105 Kiel, Germany

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BMC Research Notes 2010, 3:224  doi:10.1186/1756-0500-3-224

Published: 10 August 2010

Additional files

Additional file 1:

Amino acid alignment of NOD2 and NOD2-C2. ClustalW output for the amino acid sequences of NOD2-C2 and partial of NOD2 (full length 1040 aa). NOD2 CARD domains as assessed by Ogura et al. [24] are highlighted by grey boxes. Amino acid conservation is indicated by the following symbols: (*) single, fully conserved residue, (:) conservation of strong groups, (.) conservation of weak groups and (-) no consensus.

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