Distribution of log2 ratios for specific chromosomes or chromosomal regions. Distribution of log2 ratios of all probes within six specific chromosomes or chromosomal regions; the CDKN2A locus in 9p21.3, 9p21.3-p21.2, chromosome 2, chromosome 8, 1q (all in TC-32) and the MDM2 locus in 12q15 (in OSA) (representing 0, 1, 2, 3, 4 and >10 copies, respectively) for all microarray platforms for A) normalized data and B) normalized data that have been smoothed using Gaussian smoothing with a window size of 50 kb and standard deviation of 10 kb. Smoothing was not possible for the small regions representing 0 and >10 copies (the CDKN2A and MDM2 loci) due to insufficient number of probes.
Kresse et al. BMC Research Notes 2010 3:223 doi:10.1186/1756-0500-3-223