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Open AccessTechnical Note

Model selection in the reconstruction of regulatory networks from time-series data

Eugene Novikov email and Emmanuel Barillot email

Service Bioinformatique, Institut Curie, 26 Rue d'Ulm, 75248 Paris Cedex 05, France

author email corresponding author email

BMC Research Notes 2009, 2:68doi:10.1186/1756-0500-2-68

Published: 5 May 2009

Additional files

Additional file 1:

Kernel functions. Rationale for using the kernel functions from Table 1.

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Additional file 2:

Identifiability note. Discussion on the parameter identifiability for the developed models.

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Additional file 3:

Modified forward selection (FS) algorithm. Description and testing of the modified version of the FS algorithm.

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Additional file 4:

Adaptive model selection (AMS). Description of the AMS algorithm to identify the kernel function that reconstructs the prior links with the highest accuracy.

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Additional file 5:

Simulated and experimental data. Details on the artificial and real systems used for testing and description of the testing procedure.

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Additional file 6:

Independent artificial data. Testing of the AMS algorithm using independent set of artificial data described in [5].

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Additional file 7:

Discussion. Discussion and perspectives for further research.

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