Short Report

Assessment of anti-cyclic citrullinated peptide in psoriatic arthritis

Nermeen SA Abdel Fattah¹ , Hanan E Hassan² , Zenab A Galal³ and El Sayed E El Okda⁴

¹Department of Dermatology and Venereology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

²Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt

³Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

⁴Department of Community Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt

author email corresponding author email

BMC Research Notes 2009, 2:44doi:10.1186/1756-0500-2-44

Published:	19 March 2009

Abstract

Background

Anti-cyclic citrullinated peptides (anti-CCP) are highly specific diagnostic and prognostic markers for rheumatoid arthritis (RA). They have been also found in psoriatic arthritis (PsA), with controversies as regards clinical and radiological associations. The current study assessed anti-CCP in PsA and determined its clinical and radiological associations.

Methods

Four groups contributed to this study. 40 PsA, 40 psoriasis without arthritis, 40 RA and 40 healthy controls. They were tested for anti-CCP. Clinical and radiological data were collected and statistically compared between anti-CCP-positive and -negative PsA patients.

Results

Seven PsA (17.5%) and 34 RA (85%) were seropositive for anti-CCP. Patients of other groups were anti-CCP-negative. Regarding anti-CCP concentrations, highly significant difference existed between different groups and between anti-CCP-positive and -negative PsA. Significantly higher numbers of involved, swollen and tender joints, deformities and functional impairment of peripheral joints and radiological changes were found in anti-CCP-positive PsA.

Conclusion

Anti-CCP may be found in PsA and are associated with higher number of involved, swollen and tender joints, with deformities and functional impairment of peripheral joints and with erosive arthritis.