Figure 1.

PET image, transverse section, of a living rat brain following perispinal extrathecal administration of ⁶⁴Cu-DOTA-etanercept, imaged 5 to 10 minutes following etanercept administration. The pattern is consistent with penetration of ⁶⁴Cu-DOTA-etanercept into the cerebrospinal fluid in the lateral and third ventricles. Note the horizontal linear enhancement within the lateral ventricles which is suggestive of accumulation of tracer within the choroid plexus.