Additional file 1.

Detailed materials and methods. Detailed materials and methods are outlined here, including the methods used to build the phylogeny and the method used to infer ROL values. Three supplementary figures are also included, showing the phylogeny, the relationship between ROL and deletion strain growth phenotype, and the sensitivity of ROL values to changes in the ratio of gene loss to gene gain.

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Silander and Ackermann BMC Research Notes 2009 2:2   doi:10.1186/1756-0500-2-2