BMC Research Notes


Open Access Short Report

Blind search for post-translational modifications and amino acid substitutions using peptide mass fingerprints from two proteases

Harald Barsnes1*, Svein-Ole Mikalsen2 and Ingvar Eidhammer1

Author Affiliations

1 Department of Informatics, University of Bergen, PB 7803, N-5020 Bergen, Norway

2 Institute for Cancer Research, The Radium Hospital, The National Hospital Medical Center, Montebello, N-0310 Oslo, Norway

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BMC Research Notes 2008, 1:130 doi:10.1186/1756-0500-1-130

Published: 19 December 2008

Additional files

Additional file 1:

Theoretical Examples. A PDF file containing examples showing detection of modifications in an artificial dataset.

Format: PDF Size: 45KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 2:

Experimental Examples. A PDF file containing details on MS experiments performed to show the proposed usage of the algorithm and software tool.

Format: PDF Size: 108KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 3:

Supplementary Material. A PDF file containing additional information regarding a theoretical analysis of the degree of coverage and overlap between the proteases trypsin, chymotrypsin and gluC using 19,852 human proteins.

Format: PDF Size: 7.4MB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data