Table 2

Top 10 DM loci obtained with LIMMA
Locus Gene Mean β t-statistic P-value Adjusted p-value B-statistic
cg27427514 - 0.103 -5.541 6.96E-06 0.529 2.195
cg19938535 LRRC16A 0.668 4.980 3.15E-05 1.000 0.808
cg25548594 - 0.322 -4.717 6.39E-05 1.000 0.158
cg01821429 - 0.171 -4.697 6.75E-05 1.000 0.107
cg21899558 PRKAR1B 0.820 4.679 7.09E-05 1.000 0.063
cg01600516 ALOX12 0.690 4.376 1.60E-04 1.000 -0.688
cg26143874 - 0.815 4.252 2.23E-04 1.000 -0.991
cg15773974 - 0.629 4.167 2.81E-04 1.000 -1.201
cg01074767 C1RL; LOC283314 0.597 -4.046 3.87E-04 1.000 -1.495
cg03424554 WWP2 0.467 -3.990 4.49E-04 1.000 -1.633

Column 1 contains the locus ID; Column 2 the gene symbol(s) to which the probe is annotated; Column 3 the average methylation level (β) across all samples; Column 4 moderated t-statistic with standard errors shrunken to a common value; Column 5 nominal p-value; Column 6 multiple testing corrected p-value; column 7 Bayesian odd ratio of DM. In the last column in bold are the odd ratios greater than 0, suggesting differential methylation.

Lu et al.

Lu et al. BMC Medical Genomics 2014 7:12   doi:10.1186/1755-8794-7-12

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