Open Access Highly Accessed Research article

Vitamin D related genes in lung development and asthma pathogenesis

Alvin T Kho12, Sunita Sharma2348, Weiliang Qiu38, Roger Gaedigk59, Barbara Klanderman38, Simin Niu38, Chris Anderson107, James S Leeder59, Scott T Weiss2368 and Kelan G Tantisira2348*

Author Affiliations

1 Children’s Hospital Informatics Program, Boston Children’s Hospital, 320 Longwood Avenue, Boston, MA 02115, USA

2 Harvard Medical School, Boston, MA, USA

3 Channing Division of Network Medicine, Brigham and Women’s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA

4 Pulmonary Division, Brigham and Women’s Hospital, Boston, MA, USA

5 Children’s Mercy Hospital, Kansas City, MO, USA

6 Partners Health Care Center for Personalized Genetic Medicine, Boston, MA, USA

7 University of Rochester Medical Center, Rochester, NY, USA

8 Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA

9 Division of Pediatric Clinical Pharmacology and Medical Toxicology, Children’s Mercy Hospital and Clinics, 2401 Gilham Road, Kansas City, MO 64108, USA

10 Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA

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BMC Medical Genomics 2013, 6:47  doi:10.1186/1755-8794-6-47

Published: 5 November 2013

Additional files

Additional file 1: Table S1:

413 vitamin D related genes. Figure S1. Heat maps of 103 and 92 vitamin D related lung genes overlapping with the developing lung characteristic genes of C57BL6 mouse (A) and human (B) developing lung time series respectively. The expression signal of each gene in each time series has been standardized to average 0, variance 1 across their respective time intervals. Four sentinel genes – BUB1, TOP2A, SFTPB and SFTPC – included for visual reference.

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