Table 7

Common genes correlated with neurocognitive impairment in AD and HIV
Gene probe Function* Scaled intramodule connectivity kIN/max (kIN)
Up with impairment AD hippocampus HIV frontal cortex HIV basal ganglia
CTDSP2 Cancer 1.0 1.0 1.0
SASH1 Cancer 0.84 0.95 --
FBXW12 0.86 -- 0.79
HIPK2 Cancer 0.77 0.74 0.72
CASC3 Cancer 0.74 -- 0.74
CEP350 0.72 0.90 --
PGF Cancer 0.71 -- 0.73
HS1BP3 Neurologic 0.71 -- 0.72
Down with Impairment AD hippocampus HIV frontal cortex HIV basal ganglia
SCG5 Neurologic 0.96 -- 0.85
VDAC1 Mitochondria 0.95 0.99 0.92
KIAA1279 Neurologic 0.93 -- 0.70
PFDN4 0.92 0.84 --
MDH1 Mitochondria 0.90 0.84 1.0
ATP5G3 Mitochondria 0.90 0.95 0.99
DYNC1I1 Neurologic 0.89 0.83 0.83
PCMT1 Neurologic 0.86 0.98 0.90
TOMM20 Mitochondria 0.86 -- 0.92
KLC1 Microtubule 0.86 0.96 --
NDFIP1 0.86 0.73 0.84
KIFAP3 Neurologic 0.85 0.87 --
THYN1 0.85 0.74 0.78
GOT1 Mitochondria 0.84 0.83 0.84
TBC1D9 0.84 0.75 0.90
UCHL1 Neurologic 0.84 0.84 0.92
ACTR10 0.84 0.88 0.85
CISD1 Mitochondria 0.83 0.83 0.75
SMAP1 0.82 0.76 --
C14orf2 0.82 0.77 0.76
PEX11B 0.81 0.93 --
SLC4A1AP 0.81 0.71 --
COPS4 0.81 0.87 0.79
ITFG1 0.80 0.84 0.76
GLOD4 0.79 -- 0.83
DNAJA2 Mitochondria 0.78 0.74 0.73
SUCLA2 Mitochondria 0.76 0.87 0.84
NDUFB6 0.76 -- 0.78
EBNA1BP2 0.76 -- 0.72
TUBA4A 0.75 -- --
HINT1 Cancer 0.75 0.86 0.80
ATP6V1E1 Mitochondria 0.74 -- 0.75
GUCY1B3 0.72 0.83 0.91
ATP5H Neurologic 0.72 0.73 --
GPI 0.70 0.75 --
BEX1 Neurologic 0.70 -- 0.72

*Gene function was determined by reviewing information within the Online Mendelian Inheritance in Man database http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim webcite.

Levine et al.

Levine et al. BMC Medical Genomics 2013 6:4   doi:10.1186/1755-8794-6-4

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