Table 5

Enriched GO categories for common impairment genes
Genes down-regulated with impairment in both AD and HIV
Gene Category List Hits List Total Pop Hits Pop Total EASE score Bonferroni
Cytoplasm 175 259 2277 4968 5.62E-13 1.40E-09
Energy pathways 26 259 128 5016 4.16E-09 1.04E-05
Mitochondrion 48 259 396 4968 3.27E-08 8.15E-05
Tricarboxylic acid cycle 10 259 20 5016 2.24E-07 5.58E-04
Transit peptide 28 217 184 4007 1.14E-06 2.85E-03
Synaptic vesicle 10 259 30 4968 1.31E-05 3.26E-02
Genes up-regulated with impairment in both AD and HIV
Cell differentiation 10 131 90 5016 4.79E-13 1.40E-09
Activator 11 105 131 4007 1.89E-03 1.00E + 00
Repeat 42 105 1051 4007 1.98E-03 1.00E + 00
Cell communication 50 131 1363 5016 5.20E-03 1.00E + 00
Regulation of transcription 32 131 762 5016 5.70E-03 1.00E + 00
Phosphorylation 26 105 582 4007 6.18E-03 1.00E + 00

All genes in this list were correlated with MMSE in Blalock et al. [25] (R > 0.25), as well as with GCR in the current analysis of HIV brains (both FC and BG, R > 0.25).

Levine et al.

Levine et al. BMC Medical Genomics 2013 6:4   doi:10.1186/1755-8794-6-4

Open Data