Table 5

Approved or experimental compounds that target related genes
Gene symbol Drug & compound name j Status
PLK1 DB08059, DB07789, DB06963, DB06897, DB07186, BI 2536, cyclapolin 9, GW843682X, ADP, threonine, serine, pyridoxal, nocodazole, paclitaxel, phosphoserine, TAK-960 experimental
CDC7 PHA 767491 hydrochloride, BMS-863233, NMS-1116354 experimental
CDK1 flavopiridol, hymenialdisine, indirubin-3′-monoxime, olomoucine, SU9516 experimental
MTOR rapamycin, everolimus approved
CDK16 DB07766 experimental
PLK4 ADP, microplasmin, serine, fibrinogen, cysteine experimental
STK17B quercetin experimental
TTK DB01782 experimental
STK38 mercaptopurine experimental
NEK2 DB07180 experimental
AURKA Adenosine-5′-Diphosphate, phosphonothreonine, taxane, paclitaxel, serine, threonine experimental
BUB1 cytosine, paclitaxel, nocodazole experimental
SRPK1 gemcitabine, cisplatin, serine, arginine experimental
PRKCSH VU 0155069, cellobiose experimental
PKC family (PRKCH, PRKCI, PRKCSH, PRKCZ) bryostatin, aprinocarsen, enzastaurin, tamoxifen citrate, midostaurin, UCN-01 experimental
MARK2 glycogen experimental
PDGFRA imatinib, sorafenib, sunitinib, pazopanib, axitinib approved
BRD2 PFI 1, sulfadiazine, dihydrofolate experimental
CHEK2 DDUG experimental
CERK NVP 231 experimental
UCK2 DB03431, DB04272, DB02097, DB03403, DB02431, DB04005 experimental
AK2 DB01717 experimental
CHKA choline approved
RAF1 sorafenib approved
CSNK2B TMCB, TBB, ellagic acid experimental

j Gene-related drug compounds identified according to DrugBank, PharmGKB, Tocris Bioscience, HMDB, and/or Novoseek; The data were obtained from the website: http://www.genecards.org webcite and http://www.cancer.gov/drugdictionary webcite.

Wang and Simon

Wang and Simon BMC Medical Genomics 2013 6:30   doi:10.1186/1755-8794-6-30

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