Table 3

Important biological functions relevant to the genes identified
Category # Molecules Representative genes
Post-Translational Modification 65 RAF1,SRPK1,EPHB2,PHKG2,MARK1,MELK,MAPK13,CDK9, SRPK2,PLK4,STK17B,EIF2AK1,CHKA,RPS6KB1,MAP3K9
Cell Cycle 42 CDK1,NEK2,PIK3CA,SRPK1,CDC7,CDK11A,CDK11B,MELK, CDK9,TTK, BRAF, SRPK2,PLK4,MTOR,CLK1
Cellular Development 57 BRAF,EPHB2,CDC7,MAP3K4,MAPK13,CDK9,RIPK2,CDK16, GNE,EIF2AK1,RPS6KB1,EPHA1,AURKA,CHKA,SIK1
Cellular Growth and Proliferation 62 MTOR,EPHB2,CDC7,MELK,MAPK13,CDK9,SRPK2,PLK4, RIPK2,STK17B,EIF2AK1,GNE,NEK2,RPS6KB1,EPHA1
Cell Death and Survival 61 TTK,SRPK1,EPHB2,CDC7,MELK,MAPK13,MAP3K4,CDK9, SRPK2,PLK4,RIPK2,STK17B,GNE,EIF2AK1,MTOR
Cell Signaling 28 PLK1,SRPK1,MARK2,MARK1,MAPK13,MAP3K4,PRKCZ, IRAK1,BRAF,SRPK2,ROR2,MTOR,NEK2,CLK1,MAP3K7
Amino Acid Metabolism 15 SRPK1,EPHB2,EPHA1,ACVR1,TTK,CDK9,PHKA2,MTOR,CLK1,ABL2,PDGFRA,TLK2,CHEK2,C8orf44-SGK3/SGK3
Small Molecule Biochemistry 29 MAST2,PIK3CA,SRPK1,EPHB2,CDK16,MARK2,TTK,CDK9, PRKCZ,PHKA2,MTOR,HK2,CLK1,NTRK1,PDGFRA
Cellular Assembly and Organization 45 CHEK2,PIK3CA,SRPK1,EPHB2,MARK2,CDC7,MARK1,STK35,TTK,PRKCZ,PRKCSH,BRAF,ROR2,PLK4,MTOR
DNA Replication, Recombination, and Repair 26 ERBB3,PIK3CA,SRPK1,CDC7,TTK,PRKCZ,BRAF,PLK4,MTOR,NEK2,NTRK1,PDGFRA,SPHK1,CHEK2,PLK1
Cancer 64 TTK,SRPK1,EPHB2,CDC7,MARK1,MELK,MAP3K4,MAPK13,STK35,SCYL2,SRPK2,PLK4,STK17B,SCYL3,EIF2AK1
Cellular Function and Maintenance 43 PIK3CA,EPHB2,MARK2,MARK1,MAPK13,CDK9,TTK,STK35,PRKCZ,PRKCSH,BRAF,ROR2,PLK4,MTOR,PLK1

Wang and Simon

Wang and Simon BMC Medical Genomics 2013 6:30   doi:10.1186/1755-8794-6-30

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