Table 2

The candidate genes with synthetic lethality to p53 identified in at least two different datasets
Symbol Name Function Reference
PLK1 polo-like kinase 1 cell cycle regulation [13-19]
CDK16 cyclin-dependent kinase 16 cell cycle regulation [20]
RYK receptor-like tyrosine kinase cellular growth and differentiation Regulation [21]
MTOR mechanistic target of rapamycin (serine/threonine kinase) cellular metabolism, growth, and proliferation Regulation [22-24]
STK17B serine/threonine kinase 17b positive regulation of apoptosis [25]
PLK4 polo-like kinase 4 cell cycle regulation [17,26]
MAST2 microtubule associated serine/threonine kinase 2 cellular growth and differentiation Regulation [27]
MAP3K4 mitogen-activated protein kinase kinase kinase 4 role in signal transduction cascades [28]
MARK2 MAP/microtubule affinity-regulating kinase 2 cell polarity and microtubule dynamics regulation [29]
CDK1 cyclin-dependent kinase 1 cell cycle regulation [13,15-17,30,31]
NEK2 NIMA (never in mitosis gene a)-related kinase 2 cell cycle regulation [14-16,30]
PRKCSH protein kinase C substrate 80K-H roles in inflammation, cell growth, signaling and death [32]
AURKA aurora kinase A cell cycle regulation [33,34]
BUB1 mitotic checkpoint serine/threonine kinase cell cycle regulation [35]
CDC7 cell division cycle 7 homolog (S. cerevisiae) cell cycle regulation [30]
SRPK1 SRSF protein kinase 1 cellular growth and differentiation Regulation [36]
TTK TTK protein kinase cell cycle regulation [14-16,37,38]
VRK1 vaccinia related kinase 1 cell cycle regulation [39,40]

Wang and Simon

Wang and Simon BMC Medical Genomics 2013 6:30   doi:10.1186/1755-8794-6-30

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