Molecular networks generated by Ingenuity Pathway Analysis using the top selected genes discriminating chronic kidney disease (CKD) from hemodialysis (HD) patients. Network, algorithmically generated based on the functional and biological connectivity among genes, was graphically represented as nodes (genes) and edges (the biological relationship between genes). Shaded nodes represented genes identified by our microarray analysis and others (empty nodes) were those that IPA automatically included because biologically linked to our genes based on evidence in the literature. Meaning of node shapes and edges are indicated. Red and green shaded genes were those used for validation by classical biomolecular techniques.
Zaza et al. BMC Medical Genomics 2013 6:17 doi:10.1186/1755-8794-6-17