Table 3

Characterization of methylation profiles of the imprinted genes in DNA of ovarian cancers.

(A) Histology


H19

GTL2

ZDBF2

PEG1

LIT1

ZAC

PEG3

SNRPN


Normal

(n = 7)

34.3 ± 11.8

34.7 ± 9.5

44.2 ± 6.6

30.7 ± 15.1

27.9 ± 12.6

33.1 ± 5.8

42.8 ± 18.5

44.9 ± 25.3

Cancer

(n = 74)

41.7 ± 17.2

39.6 ± 18.8

43.8 ± 6.6

45.9 ± 15.5*

27.9 ± 14.1

41.1 ± 6.4

41.1 ± 14.1

42.8 ± 12.9

Serous

(n = 36)

47.6 ± 18.9

38.8 ± 22.0

42.0 ± 18.5

48.9 ± 14.7*

28.8 ± 9.8

42.7 ± 16.6

40.9 ± 14.8

39.3 ± 12.2

Mucinous

(n = 9)

36.0 ± 15.0

35.2 ± 19.2

36.8 ± 14.0

47.1 ± 20.0

34.7 ± 21.4

42.2 ± 5.9

31.2 ± 11.2

42.7 ± 17.8

Endometrioid

(n = 10)

37.9 ± 14.8

30.7 ± 14.4**

57.8 ± 19.8

45.5 ± 13.7

22.8 ± 13.0

37.5 ± 11.5

46.8 ± 15.9

41.4 ± 10.8

Clear

(n = 18)

45.6 ± 20.2

54.0 ± 20.1

39.7 ± 20.8

42.2 ± 13.8

25.5 ± 12.4

40.2 ± 16.1

45.7 ± 14.5

47.8 ± 11.1

(B) Progress (Staging)


Localized (I, II)

(n = 29)

38.8 ± 14.9

40.8 ± 20.4

46.7 ± 19.4

47.8 ± 17.1

30.4 ± 16.1

41.0 ± 11.9

42.8 ± 17.8

44.2 ± 12.9

Advanced (III, IV)

(n = 45)

47.8 ± 19.6

41.3 ± 22.2

41.9 ± 19.2

45.9 ± 13.7

26.2 ± 10.0

41.1 ± 16.8

41.2 ± 12.8

40.9 ± 12.6

(C) Age


Under 44 years

(n = 17)

46.7 ± 18.5

35.3 ± 21.0

42.0 ± 20.4

48.9 ± 13.5

24.2 ± 11.7

39.9 ± 12.3

44.7 ± 14.3

36.3 ± 10.7

45-55 years

(n = 29)

39.9 ± 14.7

47.2 ± 23.0

45.8 ± 17.5

46.9 ± 15.0

30.1 ± 14.8

38.9 ± 15.5

41.9 ± 15.8

45.4 ± 11.1

Over 56 years

(n = 32)

47.4 ± 21.2

38.4 ± 18.1

42.2 ± 21.1

45.1 ± 16.2

28.2 ± 10.9

44.1 ± 15.7

40.8 ± 14.9

42.5 ± 14.5


The values in the list are mean ± SD (standard deviation). Statistically significant differences between groups are presented as *P < 0.05, and **P < 0.01 by ANOVA

Hiura et al. BMC Medical Genomics 2012 5:8   doi:10.1186/1755-8794-5-8

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