|Ten most significant GO molecular functions from the gene set enrichment analysis|
|GO Identifier||GO Molecular Function||Over-Expressed Gene1||Under-Expressed Genes2||Log Odds Ratio3||FDR P-value4|
|GO:0000287||magnesium ion binding||196||300||−0.6962||3.23E-11|
|GO:0016818||hydrolase activity, acting on acid anhydrides, in phosphorus containing anhydrides||419||521||−0.4933||5.21E-11|
|GO:0016817||hydrolase activity, acting on acid anhydrides||428||527||−0.4834||9.62E-11|
|GO:0016773||phosphotransferase activity, alcohol group as acceptor||393||475||−0.4624||5.64E-09|
|GO:0016788||hydrolase activity, acting on ester bonds||349||429||−0.4781||9.84E-09|
|GO:0030695||GTPase regulator activity||193||260||−0.5651||4.10E-07|
1Over-Expressed Genes: number of genes that have a positive association between expression and glioblastoma multiforme survival.
2Under-Expressed Genes: number of genes that have a negative association between expression and glioblastoma multiforme survival.
3Log Odds Ratio: indicates whether the category is more enriched among the genes that have a positive association between expression and survival relative to the enrichment among the genes that have a negative association between expression and glioblastoma survival (positive loge odds ratio) or vice versa (negative loge odds ratio). Extreme values indicate higher difference in the enrichment percentages between the positive and negative association groups meanwhile values close to zero indicate similar enrichment percentages between positive and negative association groups.
4FDR-adjusted P-value: False discovery rate adjusted P-value of the log odds ratio test.
Sadeque et al.
Sadeque et al. BMC Medical Genomics 2012 5:59 doi:10.1186/1755-8794-5-59