Table 7

Ten most significant GO molecular functions from the gene set enrichment analysis
GO Identifier GO Molecular Function Over-Expressed Gene1 Under-Expressed Genes2 Log Odds Ratio3 FDR P-value4
GO:0000287 magnesium ion binding 196 300 −0.6962 3.23E-11
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus containing anhydrides 419 521 −0.4933 5.21E-11
GO:0016462 pyrophosphatase activity 417 520 −0.4962 5.21E-11
GO:0016817 hydrolase activity, acting on acid anhydrides 428 527 −0.4834 9.62E-11
GO:0016773 phosphotransferase activity, alcohol group as acceptor  393 475 −0.4624 5.64E-09
GO:0016301 kinase activity 421 501 −0.4473 5.64E-09
GO:0016788 hydrolase activity, acting on ester bonds 349 429 −0.4781 9.84E-09
GO:0003723 RNA binding 357 437 −0.4741 9.84E-09
GO:0030695 GTPase regulator activity 193 260 −0.5651 4.10E-07
GO:0016874 ligase activity 205 272 −0.5501 4.10E-07

1Over-Expressed Genes: number of genes that have a positive association between expression and glioblastoma multiforme survival.

2Under-Expressed Genes: number of genes that have a negative association between expression and glioblastoma multiforme survival.

3Log Odds Ratio: indicates whether the category is more enriched among the genes that have a positive association between expression and survival relative to the enrichment among the genes that have a negative association between expression and glioblastoma survival (positive loge odds ratio) or vice versa (negative loge odds ratio). Extreme values indicate higher difference in the enrichment percentages between the positive and negative association groups meanwhile values close to zero indicate similar enrichment percentages between positive and negative association groups.

4FDR-adjusted P-value: False discovery rate adjusted P-value of the log odds ratio test.

Sadeque et al.

Sadeque et al. BMC Medical Genomics 2012 5:59   doi:10.1186/1755-8794-5-59

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