Table 4

Top 5 multi-exon genes that have significant exon-independent association with glioblastoma multiforme survival
Gene Symbol Estimate1 SE2 Fold Change3 P-value4 P-value AEU5 Exon Count6 Literature7
Sirt2 0.0337 0.0092 1.0236 3.2E-04 2.5E-03 17 [62]G
Six1 0.0056 0.0015 1.0039 3.3E-04 2.7E-01 5 [63]C
Loc100289627 0.0079 0.0022 1.0055 3.8E-04 4.3E-01 2 NA
Sema3e −0.0256 0.0066 0.9824 1.3E-04 2.4E-03 18 [64]C
Golga8j −0.0536 0.0141 0.9635 1.7E-04 1.1E-03 20 [65]C

1Estimate: change in average exon expression per additional survival month (in log2 units).

2SE: standard error of the estimate.

3Fold change: fold change in average exon expression per additional survival month.

4P-value: unadjusted P-value of the change in average exon expression per additional survival month.

5P-value AEU: non-significant (P-value > 1.0E-03) evidence of alternative exon usage.

6Exon Count: number of exons in the gene.

7Literature: review of studies that reported associations of the gene with cancers:

G: reported association of gene with glioblastoma multiforme,

C: reported association of gene with cancer other than glioblastoma multiforme,

NA: not available.

Sadeque et al.

Sadeque et al. BMC Medical Genomics 2012 5:59   doi:10.1186/1755-8794-5-59

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