Open Access Research article

Identification and characterization of alternative exon usage linked glioblastoma multiforme survival

Ahmed Sadeque1, Nicola VL Serão1, Bruce R Southey1, Kristin R Delfino1 and Sandra L Rodriguez-Zas123*

Author Affiliations

1 Department of Animal Sciences, University of Illinois Urbana-Champaign, Urbana, IL, USA

2 Department of Statistics, University of Illinois Urbana-Champaign, Urbana, IL, USA

3 Institute of Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA

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BMC Medical Genomics 2012, 5:59  doi:10.1186/1755-8794-5-59

Published: 4 December 2012

Additional files

Additional file 1:

Table S1. Lists the results for the 129 multi-exon genes that exhibit evidence of AEU at P-value < 1.0E-8. Lists the results for the 129 multi-exon genes that exhibit evidence of AEU at P-value < 1.0E-8. Table S2: Significant KEGG and GO categories enriched among the genes displaying alternative exon usage. Lists all KEGG pathways, GO Biological Processes and GO Molecular Function categories at FDR-adjusted P-value < 0.05.Table S3: Multi-exon genes that have significant exon-independent association with glioblastoma multiforme survival. Lists the results for the 24 multi-exon genes exhibiting expression associated with survival albeit no evidence of AEU at P-value < 5.0E-4. Table S4: Significant GO biological processes (levels 3-6) from the gene set enrichment analysis of the genome. Lists all biological processes at FDR-adjusted P-value < 0.05. Table S5: Significant GO molecular functions (levels 3-6) from the gene set enrichment analysis of the genome. Lists all molecular functions at FDR-adjusted P-value < 0.05. Table S6: Significant KEGG pathways (levels 3-6) from the gene set enrichment analysis of the genome. Lists all pathways at FDR-adjusted P-value < 0.05.

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Additional file 2:

Figure S1. Anapc1 exon expression, moving average, and alternative splicing models. Depicts the alternative exon expression, moving average and alternative splicing models for anaphase promoting complex subunit 1. Figure S2. Herc2 exon expression, moving average, and alternative splicing models. Depicts the alternative exon expression, moving average and alternative splicing models for HECT domain and RLD domain containing E3 ubiquitin protein ligase 2.

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