Open Access Highly Accessed Research article

Defining the genomic signature of the parous breast

Suraj Peri1, Ricardo López de Cicco2, Julia Santucci-Pereira2, Michael Slifker1, Eric A Ross1, Irma H Russo2, Patricia A Russo2, Alan A Arslan34, Ilana Belitskaya-Lévy5, Anne Zeleniuch-Jacquotte4, Pal Bordas67, Per Lenner7, Janet Åhman6, Yelena Afanasyeva4, Robert Johansson8, Fathima Sheriff2, Göran Hallmans8, Paolo Toniolo349 and Jose Russo2*

Author Affiliations

1 Department of Biostatistics and Bioinformatics, Philadelphia, PA, 19111, USA

2 Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA

3 Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY, 10016, USA

4 Division of Epidemiology, New York University School of Medicine, New York, NY, 10016, USA

5 Division of Biostatistics, Department of Environmental Medicine, New York University School of Medicine, New York, NY, 10016, USA

6 Sunderby Hospital, Luleå and the Norrbotten Mammography Screening Program, Luleå, Sweden

7 Departments of Radiation Sciences and Oncology, Umeå University, Umeå, Sweden

8 Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden

9 Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

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BMC Medical Genomics 2012, 5:46  doi:10.1186/1755-8794-5-46

Published: 11 October 2012

Additional files

Additional file 1:

Table S1. Probesets differentially expressed in Parous versus Nulliparous (p<0.001 and log2 fold change of at least 0.3). Table S2- Genes differentially expressed by full term pregnancy (P) when compared to women that did not have a full term pregnancy (GN) (p<0.001 and log2 fold change of at least 0.3). Table S3. Genes differentially expressed in Parous (P) versus Nulligravidas (NG) (p<0.001 and log2 fold change of at least 0.3). Table S4. Comparison between biological processes that are over-represented in the two studies. Figure S1- Hierarchical clustering of differentially expressed probesets in parous and nulliparous women (samples were not clustered). Red represents expression values above the median across all samples, and green represents values below the median. The left portion of the figure is composed by nulliparous (NP) samples and the right portion is composed by parous (P) samples. ‘U’ represents the intensity of up-regulated probesets among parous samples whereas ‘D’ represents the intensity of down-regulated probesets.

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