Table 2

Concordance of functional annotation cluster (using DAVID®) with the four clusters identified based on differential gene expression
Description Cluster 1 Cluster 2 Cluster 3 Cluster 4
Number of genes
Total 1378 2005 428 642
Identified as human by DAVID 1332 1932 416 617
Mapped by DAVID with GO terms 1187 (86.1%) 1704 (85.0%) 380 (88.8%) 532 (82.9%)
Functional cluster rank (enrichment score*)
1 Mitochondria Mitosis Vacuole Anti-apoptosis
(12.08) (24.40) (10.18) (2.72)
2 Ribosomes Kinetochore Endocytosis Kinase binding
(7.72) (16.34) (2.82) (2.67)
3 Catabolism Intracellular organelle Cell fraction Apoptosis regulation
(6.53) (12.53) (2.56) (2.59)
4 Intracellular organelle DNA Replication Metal ion binding Intracellular organelle
(4.80) (11.96) (2.37) (2.25)
5 Ubiquitination DNA Repair Lysosome Metal ion binding
(4.10) (11.85) (1.86) (2.05) and
Tyrosine kinase activity
(2.05)

DAVID Database for Annotation, Visualization and Integrated Discovery; GO gene ontology. enrichment scores are the average –log10 p-values for the genes loading onto the specified functional cluster.

Kulkarni et al.

Kulkarni et al. BMC Medical Genomics 2012 5:37   doi:10.1186/1755-8794-5-37

Open Data