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Open Access Research article

Polymorphism in glutamate cysteine ligase catalytic subunit (GCLC) is associated with sulfamethoxazole-induced hypersensitivity in HIV/AIDS patients

Danxin Wang1*, Amanda Curtis1, Audrey C Papp1, Susan L Koletar2 and Michael F Para2

Author Affiliations

1 Department of Pharmacology, Program in Pharmacogenomics, School of Biomedical Science, College of Medicine, Ohio State University, Columbus, OH, 43210, USA

2 Division of Infectious Diseases, Internal Medicine, College of Medicine, Ohio State University, Columbus, OH, 43210, USA

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BMC Medical Genomics 2012, 5:32  doi:10.1186/1755-8794-5-32

Published: 23 July 2012

Additional files

Additional file 1 :

Table S1 and S2. Association between promoter SNP rs17883901 or 5’UTR GAG trinucleotide polymorphism in GCLC and SMX-induced hypersensitivity. Distribution of 5’UTR GAG trinucleotide repeats in patients with or without hypersensitivity. Chi-square test P=0.319.

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