Open Access Highly Accessed Research article

Network analysis identifies a putative role for the PPAR and type 1 interferon pathways in glucocorticoid actions in asthmatics

Diego Diez17, Susumu Goto1, John V Fahy24, David J Erle234, Prescott G Woodruff24, Åsa M Wheelock5* and Craig E Wheelock16*

Author Affiliations

1 Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto, 611-0011, Japan

2 Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA

3 Lung Biology Center, University of California San Francisco, San Francisco, CA, USA

4 Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA

5 Respiratory Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

6 Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institutet, Stockholm, Sweden

7 Laboratory of Bioinformatics and Genomics, World Premier International Immunology Frontier Research Center, Osaka University, Osaka, 565-0871, Japan

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BMC Medical Genomics 2012, 5:27  doi:10.1186/1755-8794-5-27

Published: 19 June 2012

Additional files

Additional file 1:

Table S1. Stat_analysis_results.xlsx (Microsoft Excel XLSX) Lists of genes found significantly changed in the statistical analysis.

Format: XLSX Size: 201KB Download file

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Additional file 2:

Table S2. Func_enrich_results.xlsx (Microsoft Excel XLSX) Results for KEGG pathways and GO terms functional enrichment analysis.

Format: XLSX Size: 131KB Download file

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Additional file 3:

Supp_material.pdf (Adobe PDF) Supplementary information and figures for the main manuscript [11,52,54].

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This file can be viewed with: Adobe Acrobat Reader

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Additional file 4:

Table S4. Promoter analysis.xlsx (Microsoft Excel XLSX) Results from Pscan promoter enrichment analysis with JASPAR and TRANSFAC, and results from Cscan ChIP-seq analysis.

Format: XLSX Size: 101KB Download file

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Additional file 5:

Table S5. Interferon_regulated_genes.xlsx (Microsoft Excel XLSX) List of known interferon-regulated genes from the FDR set.

Format: XLSX Size: 52KB Download file

Open Data