Table 2

Human small airway epithelium MUC5AC-associated core genes1,2
Mucus components Mucin producing cell differentiation-related Post-translational modification of mucin Vesicle transport Endoplasmic reticulum stress-associated Secretory granule- associated Mucus secretion-related regulators Mucus hypersecretory- related ion channels
Transcription factors Pathways or meditators
TFF3 SPDEF HES1 AGR2 MIA3 CREB3L1 SYTL2 PRSS23 SLC12A2
TFF1 FOXA3 TSTA3 GNE SURF4 EDEM3 RAB3D PLCE1 CLCA2
SOX2 LRRFIP2 GALNT4 KDELR2 XBP1 SCIN DGKA SCNN1A
KLF4 KRAS GALNT7 KDELR3 EIF2AK3 STXBP6 ITPR3 GABRP
MAPK13 GALNT12 ITSN1 RAB27B PRKCD
RPS6KA3 PDIA5 ERGIC1 SYTL4
CTSC FUT3 CKAP4 SYTL5
SERPINB4 FUT6 GOSR1 GSN
PLA2G4A ST6GAL1 SYNJ2BP RIMS1
ST8SIA1 MPPE1 CASK
CHST6 SEC31A MYO5B
GALNT5 ARF4 MYO5C
GALNT6 VPS13D PCLO
SEC22B PAM
TPD52

ATP6V0A4

KIF5B

CDC42EP5

1 Genes with a role in mucus production or mucus secretion (based on the literature) were selected from the significantly up-regulated genes in nonsmoker high-MUC5AC expressors compared to nonsmoker low-MUC5AC expressors (see Supplemental Methods for complete criteria).

2 References for the functions of each gene are in Additional file 1: Table S1. See Additional file 1: Figure S1, S2 for the schematic illustration of the functions of these genes relevant to MUC5AC-production/secretion.

Wang et al.

Wang et al. BMC Medical Genomics 2012 5:21   doi:10.1186/1755-8794-5-21

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