Table 9

Top ten genes whose transcript levels are correlated with methylation of CpG sites in MSX1, CDK2 and GRB10

Tissue

Methylation Gene

CpG ID

Expression Gene

Transcript ID

Correlation1

Gene Name


Blood

MSX1

cg14167596

APOE

ILMN_1740938

0.76

Apolipoprotein E

cg14167596

CGA

ILMN_1734176

0.70

Glycoprotein Hormones, Alpha Polypeptide

cg03199651

KRT6C

ILMN_1754576

0.69

Keratin 6 C

cg14167596

PAPPA

ILMN_1721770

0.67

Protein Kinase C And Casein Kinase Substrate in Neurons 1

cg14167596

PSG4

ILMN_1693397

0.67

Pregnancy Specific Beta-1-Glycoprotein 4

cg26615830

DCN

ILMN_2347145

0.65

Decorin

cg14167596

PSG6

ILMN_2309615

0.65

Pregnancy Specific Beta-1-Glycoprotein 6

cg14167596

CSH1

ILMN_1693617

0.65

Chorionic somatomammotropin hormone 1 (placental lactogen)

cg14167596

GH2

ILMN_1659354

0.65

Growth Hormone 2

cg14167596

ADAM12

ILMN_1726266

0.65

ADAM Metallopeptidase Domain 12

Placenta

CDK2

cg04108502

CXCL11

ILMN_2067890

0.74

Chemokine (C-X-C Motif) Ligand 11

cg04108502

HLA-DPB1

ILMN_1749070

0.70

Major Histocompatibility Complex, Classii, DP Beta 1

cg04108502

CXCL9

ILMN_1745356

0.68

Chemokine (C-X-C Motif) Ligand 9

cg04108502

GBP4

ILMN_1771385

0.68

Guanylate Binding Protein 4

cg04108502

GBP5

ILMN_2114568

0.67

Guanylate Binding Protein 5

cg04108502

UBD

ILMN_1678841

0.66

Ubiquitin D

cg04108502

VCY

ILMN_1683872

0.66

Variable charge, Y-linked

cg04108502

HLA-DRB3

ILMN_1717261

0.66

Major Histocompatibility Complex, Class II, DR Beta 3

cg04108502

CD3D

ILMN_2261416

0.65

CD3d molecule, delta (CD3-TCR complex)

cg04108502

CETP

ILMN_1681882

0.65

Cholesteryl ester transfer protein, plasma

GRB10

cg20651681

SHROOM2

ILMN_1681777

0.68

Shroom Family Member 2

cg20651681

MESDC1

ILMN_1781565

0.67

Mesoderm Development Candidate 1

cg20651681

CCDC146

ILMN_1790555

0.67

Coiled-Coil Domain Containing 146

cg20651681

VANGL2

ILMN_1715647

0.67

Vang-Like2 (Vangogh, Drosophila)

cg06790324

SCG2

ILMN_1703178

0.66

Secretogranin II

cg20651681

STGC3

ILMN_1807244

0.66

hypothetical STGC3

cg06790324

ABHD14B

ILMN_2227533

0.66

Ab Hydrolase Domain Containing 14B

cg20651681

TLL1

ILMN_1699814

0.66

Tolloid-Like 1

cg20651681

SOD1

ILMN_1662438

-0.65

Superoxide Dismutase 1, Soluble

cg06790324

INPP5E

ILMN_1811301

0.65

Inositol polyphosphate-5-phosphatase, 72 kDa


Genes in bold have suggested role in fetal or placental growth and development

1 Pearson correlation coefficient (P ≤ 0.01)

Turan et al. BMC Medical Genomics 2012 5:10   doi:10.1186/1755-8794-5-10

Open Data