Table 8

Each of the two random permutation six-gene models that also had positive R2 in the Infinium data set (from Table 7) were combined with each random permutation seven-gene model that achieved an R2 higher than the L1 Infinium model (25 models) for a total of 50, 13 gene models

Data Set

Genes in model

Adjusted R2 and stability when tested on Infinium Data

Genes in resulting model

Gene name


GoldenGate gene

model which achieved R2 = 0.48 (stability 44/48) on the Infinium Data

BEST1

IMPDH2

0.87 (44/48)

CTTN

GMDS

Cortactin

GDP-mannose 4,6-dehydratase

OSBPL5

IMPDH2

IMP (inosine 5'-monophosphate) dehydrogenase 2

PAX3

OSBPL5

oxysterol binding protein-like 5

PSMC3

PAX3

paired box 3

SERPINF1

PSMC3

proteasome (prosome, macropain) 26S subunit, ATPase, 3

Infinium gene model

which achieved better

R2 than our model

CTTN

REG1B

regenerating islet-derived 1 beta

GMDS

RUVBL1

RuvB-like 1 (E. coli)

REG1B

SERPINF1

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1

VPS52

VPS52

vacuolar protein sorting 52 homolog

RUVBL1

KIAA241


Only one of the 50 models achieved higher R2 than the L1 13 gene model. Genes in bold have suggested role in fetal or placental growth and development

Turan et al. BMC Medical Genomics 2012 5:10   doi:10.1186/1755-8794-5-10

Open Data