Additional file 3.

Batch effect correction by distance weighted discrimination (DWD). DWD effectively removes batch effects. However, the numbers of significant CpGs associated with outcome of study are all lower than EB corrected data in Table 1 of the main text. Failure to incorporate biological covariates in the adjustment model is likely to compromise true biological signals.

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Sun et al. BMC Medical Genomics 2011 4:84   doi:10.1186/1755-8794-4-84