A hypothetical network based on differentially expressed transcription factors and DEmiRNAs. Molecular interactions obtained from protein-protein interactions, KEGG pathway interactions, putative transcriptional regulatory interactions derived from 1423 DEGs, and predicted DEmiRNA and DETF interactions were combined. (A). The network containing 689 nodes composed of 22 DETFs (open squares), 618 DEGs (filled circles) and 49 DEmiRNAs (filled triangles) and 1391 non-redundant interactions was generated. The network can be grouped into 7 modules (as indicated) based on the connectivity of nodes - the more interacted nodes are grouped together. (B) This figure displays only the network consisting of the DETF (with known binding sites) and their cognate DEmiRNAs. The transcription factors, which do not have well characterized binding site information were not used in prediction of interactions, and are shown as open circles.
Cho et al. BMC Medical Genomics 2011 4:8 doi:10.1186/1755-8794-4-8