Inverse relationships between myoblast- and myotube-specific gene expression changes and FSHD-specific changes. A. Genes up- or downregulated in FSHD vs. control myoblasts often showed opposite changes in expression in control myoblasts vs. 19 non-muscle cell types. This heat map of log2 expression ratios for genes upregulated > 2-fold (p < 0.01) in FSHD vs. control myoblasts illustrates that these genes were often downregulated in control myoblasts vs. diverse non-muscle cell cultures and that there was the converse relationship for genes downregulated in FSHD vs. control myoblasts and upregulated in control myoblasts vs. non-muscle cell cultures. Both associations were significant (p < 0.01). B. This heat map is analogous to that of Panel A except that it is for myotubes instead of myoblasts.
Tsumagari et al. BMC Medical Genomics 2011 4:67 doi:10.1186/1755-8794-4-67