Differentiation of control myoblasts to myotubes involved mostly increases in gene expression that were often diminished during FSHD myogenesis. This heat map of log2 expression values (see color key) for genes upregulated > 2-fold in control myotubes vs. myoblasts shows that many genes that were upregulated during normal myogenesis (red in first column) were downregulated in FSHD vs. control myotubes (green in the corresponding portion of the second column). A small fraction of these were also downregulated in FSHD vs. control myoblasts (green in the corresponding portion of the third column).
Tsumagari et al. BMC Medical Genomics 2011 4:67 doi:10.1186/1755-8794-4-67