Research article
Combinations of newly confirmed Glioma-Associated loci link regions on chromosomes 1 and 9 to increased disease risk
1 Bioinformatics Program, Boston University, 24 Cummington Street, Boston, MA 02215, USA
2 Department of Mathematics and Statistics, Boston University, 111 Cummington Street, Boston, MA 02215, USA
3 Department of Biomedical Engineering, 44 Cummington Street, Boston University, Boston, MA 02215 USA
BMC Medical Genomics 2011, 4:63 doi:10.1186/1755-8794-4-63
Published: 9 August 2011Additional files
Additional file 1:
Table S1. We divided the glioma samples from TCGA into 2 independent samples (P1 and P2), conducting a GWA analysis on each using the same i-control population. If the use of a single control created bias, we'd expect overlapping results. In fact the results are quite different.
Format: DOC Size: 43KB Download file
This file can be viewed with: Microsoft Word Viewer
Additional file 2:
Table S2. The top 406 SNPs reported by Wrensch et al, (2009) with their AGS pvalues (P1), TCGA pvalues (P2), and Stoufer's combined pvalues(P12).
Format: DOC Size: 721KB Download file
This file can be viewed with: Microsoft Word Viewer
Additional file 3:
Table S3. Pairwise and triplet SNP combinations with odds ratios greater than 3. Combinations of 12 Confirmed Glioma associated SNPs.
Format: DOC Size: 217KB Download file
This file can be viewed with: Microsoft Word Viewer
Additional file 4:
Table S4. KEGG pathways with SNPs (p < 0.001) from both AGS and TCGA studies. Boldface denotes pathways with significant genes that are common to both populations.
Format: DOC Size: 348KB Download file
This file can be viewed with: Microsoft Word Viewer
