Table 4

Association of SNPs with obesity under different genetic models

SNP

Gender

Genetic model

Obese (n)

Control (n)

OR (95% C.I.)

P value§§


rs2116830

All

Additive*

3267/1280/126

3060/1520/192

1.27 (1.13, 1.43)

4.2 ×10-05

(KCNMA1)

Dominant**

4547/126

4580/192

1.51 (1.20, 1.89)

0.0004

Recessive§

3267/1406

3060/1712

1.30 (1.19, 1.42)

2.5 × 10-09

Male

Additive

1127/475/48

1311/641/80

1.20 (1.00, 1.44)

0.055

Dominant

1602/48

1952/80

1.37 (0.95, 1.97)

0.092

Recessive

1127/523

1311/721

1.19 (1.03, 1.36)

0.016

Female

Additive

2138/805/78

1747/879/111

1.32 (1.14, 1.53)

0.00024

Dominant

2943/78

2626/111

1.60 (1.19, 2.14)

0.0019

Recessive

2138/883

1747/990

1.37 (1.23, 1.53)

2.0 ×10-08

rs988712

All

Additive

2952/1504/183

2662/1737/327

1.41 (1.28, 1.55)

1.1 ×10-12

(BDNF)

Dominant

4456/183

4399/327

1.81 (1.50, 2.18)

3.7 × 10-10

Recessive

2952/1687

2662/2064

1.36 (1.25, 1.47)

6.2 × 10-13

Male

Additive

1041/519/82

1106/753/140

1.27 (1.10, 1.46)

0.0011

Dominant

1560/82

1859/140

1.43 (1.08, 1.90)

0.012

Recessive

1041/601

1106/893

1.40 (1.22, 1.60)

8.7 × 10-07

Female

Additive

1909/985/101

1554/983/187

1.51 (1.33, 1.71)

1.47 × 10-10

Dominant

2894/101

2537/187

2.11 (1.65, 2.71)

3.4 × 10-09

Recessive

1909/1086

1554/1170

1.32 (1.19, 1.47)

2.4 × 10-07


* Numbers of subject with genotype GG, GT or TT, ** Numbers of subject with genotype GG or GT versus number of subjects with genotype TT, and § numbers of subject with genotype GG versus GT and T where G is the effect allele;

§§Model based analysis was carried out by logistic regression, se Statistical analysis.

Jiao et al. BMC Medical Genomics 2011 4:51   doi:10.1186/1755-8794-4-51

Open Data