Table 1

Cohorts for genetic studies

obese cases

lean and population-based controls

Cohort

SNP§

Nationality

female/male

BMI* (kg/m2)

age* (years)

female/male

BMI* (kg/m2)

age* (years)


Discovery

1

406,177

Swedish

131/33§

44.7 ± 4.7

43.8 ± 12.6

137/26

22.2 ± 1.8

51.6 ± 6.1

Replication

2

700

Swedish

370/90§§

44.6 ± 4.6

42.2 ± 13.2

206/41

22.6 ± 1.7

51.6 ± 5.3

Replication

3

21

Swedish

1025/789

37.1 ± 5.4

46.6 ± 11.4

819/885

22.8 ± 1.7

48.7 ± 10.8

Replication

4**

21

French

641/344

33.7 ± 8.2

14.1 ± 5.0

289/243#

18.7 ± 3.3

11.8 ± 1.6

Replication

5

2

French

682/246

48.5 ± 7.6

43.0 ± 12.1

1630/1108#

23.8 ± 3.5

49.7 ± 6.3

Replication

6**

2

German

278/209

33.4 ± 6.8

14.4 ± 3.7

271/171

18.3 ± 1.1

16.1 ± 5.8

Total

3127/1711

3353/2474


* Values are mean ± SD; ** Cohorts comprising children in which case BMI Z-scores were used to define obesity status as defined in Methods.

§ Number of SNPs genotyped in each cohort. The 700 most significantly obesity associated SNPs in the GWA were analyzed in cohort 2 (threshold P = 0.003). Subsequently, nominal association with obesity was used as threshold to determine whether a SNP would be followed up by genotyping additional cohorts. # population-based controls

Jiao et al. BMC Medical Genomics 2011 4:51   doi:10.1186/1755-8794-4-51

Open Data