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Genome wide association study identifies KCNMA1 contributing to human obesity

Hong Jiao12*, Peter Arner3, Johan Hoffstedt3, David Brodin1, Beatrice Dubern4, Sébastien Czernichow4, Ferdinand van't Hooft5, Tomas Axelsson6, Oluf Pedersen78, Torben Hansen78, Thorkild IA Sørensen9, Johannes Hebebrand10, Juha Kere12*, Karin Dahlman-Wright1, Anders Hamsten5, Karine Clement11 and Ingrid Dahlman3

Author Affiliations

1 Department of Biosciences and Nutrition, Karolinska Institutet, SE-141 83 Huddinge, Sweden

2 Clinical Research Centre, Karolinska University Hospital, SE-141 57 Stockholm, Sweden

3 Department of Medicine at Karolinska Institutet and Karolinska University Hospital, SE-141 86 Stockholm, Sweden

4 INSERM, U-557/INRA U-1125, CNAM, UP13, CRNH-IdF, 93017 Bobigny, France; University Paris 13, 93017, Bobigny, France; AP-HP, Avicenne Hospital, 93017 Bobigny, France

5 Cardiovascular Genetics Group, Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, SE-17176 Stockholm, Sweden

6 Department of Medical Sciences, Molecular Medicine, Science for Life Laboratory, Uppsala University, Uppsala, Sweden

7 Hagedorn Research Institute, Gentofte,, Copenhagen, Denmark

8 Center of Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, Denmark

9 Institute for Preventive Medicine, Copenhagen University Hospital, Center for Health and Society, Copenhagen, Denmark

10 Department of Child and Adolescent Psychiatry of the University of Duisburg-Essen, Essen, Germany

11 INSERM, U-872, Nutriomique (team 7) 75006 Paris, France; University Pierre and Marie Curie-Paris 6, Cordeliers Research Center, 75006 Paris, France; AP-HP, Pitié-Salpétrière Hospital, 75013 Paris, France

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BMC Medical Genomics 2011, 4:51  doi:10.1186/1755-8794-4-51

Published: 28 June 2011

Additional files

Additional file 1:

Supplementary methods, figures and tables. This file contains additional methodological description of the GWA. It also contains Figure S1 with Q-Q and S2 with Manhattan plots. Finally this file contains Tables S1 showing chromosomal distribution of analyzed 500K SNPs, S2 showing results of replication genotyping, S3 showing association of rs2116830*G with BMI and obesity in population-based samples, and S4 showing replication of published obesity and BMI loci identified by GWA.

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