Figure 1.

A and B Sources of variation in methylation data. Statistical significance of the different sources of variation in the methylation data estimated by 4-way ANOVA models. F-ratio for each factor (source) represents the F-statistics for that factor/F-statistics for error (noise). 1A shows the result in all 27,578 loci and 1B shows similar result only in the autosomal loci (n = 26,486) depicting the effect of sex chromosomal markers.