Probability of lifetime glioblastoma survival across age in females and males for protein kinase, C beta (Prkcb). Probability of glioblastoma survival across age for Females and Males with Low (25th percentile) and High (75th percentile) expression level of protein kinase, C beta (Prkcb). Consistent with the hazard ratio estimates for females (HR = 1.31) and males (HR = 5.21), the probability of survival in individuals with high levels of Prkcb declines before than in individuals with lower levels of Prkcb. Due to the significant interaction between the expression of Prkcb and gender, the probability of survival for females with high level of the gene declines faster than the probability of survival for males with low level of the gene.
Serão et al. BMC Medical Genomics 2011 4:49 doi:10.1186/1755-8794-4-49