Table 3

Genes identified in figure 3 with p-value < 0.05 by t-test

Gene Symbol

Ovarian p-value

Betweenness

(mean = 3.8E-4)

Degree

(mean = 9.71E-4)

Connected nodes


c-KIT

(v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, also called KIT or C-kit receptor)

3.53E-07

0.00178

0.006483


GRB2

(growth factor receptor-bound protein 2)

5.74E-06

0.020155

0.023064

V


AKT2

(v-akt murine thymoma viral oncogene homolog 2)

0.022784

3.89E-04

0.002369

V


PIK3CG

(phosphoinositide-3-kinase, catalytic, gamma polypeptide)

1.29E-04

9.77E-05

0.001247


Genes listed in this table are significant in ovarian expression data with p-value < 0.05. Moreover, the betweenness and degree centrality of each gene are also listed. Both GRB2 and AKT2 gene are connected nodes; which indicates they pass down signals between pathways. GRB2 with significant betweenness and degree centrality indicates it has potential to act as a "hub node" in biological interaction networks and to involve in chemoresistant mechanisms as well.

Chao et al. BMC Medical Genomics 2011 4:23   doi:10.1186/1755-8794-4-23

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