Table 1

The identified significant proteins in lung carcinogenesis

Protein symbol

CRV

p-value

Functional annotation*

Literature evidence§


Cell growth

Cell survival

Cell migration

MAPK1

8.3418

< 1e-5

+

+

+

[31,32]

SMAD2

7.7901

< 1e-5

+

+

+

[36]

CREBBP

5.7870

0.00002

+

[44]

EGFR

4.3635

0.00086

+

+

+

[39-41]

AR

4.0966

0.00159

+

+

+

[49]

UBC

4.0331

0.00180

SRC

3.9446

0.00218

+

+

+

[51,63]

FGFR1

3.9227

0.00237

+

+

[42]

BRCA1

3.9049

0.00243

+

+

[58]

ESR1

3.8409

0.00295

+

+

+

[50]

INSR

3.7946

0.00329

+

+

[43]

PTK2

3.6758

0.00432

+

+

+

[63,64]

HSP90AA1

3.6732

0.00436

+

+

+

[54]

CALM1

3.6363

0.00482

+

POLR2A

3.5701

0.00547

CSNK2A1

3.4128

0.00761

+

+

[61]

PRKACA

3.3688

0.00856

+

CTNNB1

3.2935

0.00994

+

+

+

[45]

SP1

3.2397

0.01133

+

+

[59]

SMAD4

3.1947

0.01266

+

+

+

[36]

E2F1

3.1382

0.01407

+

+

[46]

YWHAZ

3.1212

0.01467

+

[52]

MEPCE

3.0968

0.01545

AKT1

3.0193

0.01857

+

+

+

[62]

PLCG1

2.9654

0.02069

+

[66]

MYC

2.8987

0.02385

+

+

[47]

MAPK3

2.8545

0.02654

+

+

+

[31,32]

NCOA6

2.8132

0.02892

+

+

FYN

2.7833

0.03089

+

+

[48]

MAPK8IP3

2.7746

0.03141

+

YWHAQ

2.7582

0.03242

+

[53]

TRAF6

2.7150

0.03535

+

[57]

SMAD1

2.6940

0.03697

+

+

+

[37]

SMAD3

2.6815

0.03815

+

+

+

[36]

MAPK14

2.6727

0.03894

+

+

+

[34]

TP53

2.6522

0.04056

+

+

+

[40,41,55]

XRCC6

2.6270

0.04263

+

EZR

2.6213

0.04314

+

[67]

TSC2

2.6116

0.04401

+

+

+

[65]

HGS

2.5730

0.04744

+


The full names of these proteins according to UniProt database http://www.uniprot.org/ webcite are listed in Additional file 2.

* The functional annotations are from the Gene Ontology database http://www.geneontology.org/ webcite and literatures.

§ The literature evidences indicate that overexpression/dysregulation of the specific protein or mutation of the corresponding gene would result in carcinogenesis.

Wang and Chen BMC Medical Genomics 2011 4:2   doi:10.1186/1755-8794-4-2

Open Data