Open Access Research article

Gene expression in cardiac tissues from infants with idiopathic conotruncal defects

Douglas C Bittel1*, Merlin G Butler2, Nataliya Kibiryeva1, Jennifer A Marshall3, Jie Chen4, Gary K Lofland3 and James E O'Brien3

Author Affiliations

1 Section of Medical Genetics and Molecular Medicine, Children's Mercy Hospitals and Clinics and University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA

2 Departments of Psychiatry & Behavioral Sciences and Pediatrics, University of Kansas, Medical Center, Kansas City, KS, USA

3 Section of Cardiovascular and Thoracic Surgery, Children's Mercy Hospitals and Clinics and University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA

4 Department of Mathematics and Statistics, University of Missouri-Kansas City, Kansas City, MO, USA

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BMC Medical Genomics 2011, 4:1  doi:10.1186/1755-8794-4-1

Published: 5 January 2011

Additional files

Additional file 1:

Table S1. Estimates of intersample variability. Estimates of the variation between samples.

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Additional file 2:

Table S2. Canonical pathways associated with altered gene expression in TOF. List of pathways associated with genes with changes expression in TOF relative to controls, p value and gene names. Identified using Ingenuity Pathways Analysis (IPA).

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Additional file 3:

Figure S1, WNT pathway. WNT canonical pathway. Color corresponds to increase (red) or decrease (green) in signal intensity (expression) of genes in TOF subjects relative to control subjects (developed using the Ingenuity Pathways Analysis program).

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Additional file 4:

Figure S2, Notch pathway. Notch canonical pathway. Color corresponds to increase (red) or decrease (green) in signal intensity (expression) of genes in TOF subjects relative to control subjects (developed using the Ingenuity Pathways Analysis program).

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Additional file 5:

Table S3. List of genes in the WNT pathway with fold change in TOF relative to controls. Complete list of genes from the WNT pathway and the fold change in the right ventricle from subjects with TOF relative to control subjects.

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Additional file 6:

Table S4. List of genes in the Notch pathway with fold change in TOF relative to controls. Complete list of genes from the Notch pathway and the fold change in the right ventricle from subjects with TOF relative to control subjects.

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Additional file 7:

Table S5. Ontological analysis of genes with a significant change of expression between subjects with TOF and controls. Ontological analysis of clustered genes with a similar pattern of expression across the three tissues examined (right ventricle, pulmonary valve and pulmonary artery).

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