A mitochondrial phenotype is the most prominent molecular feature of BHDS renal tumors. A) Top differentially expressed gene sets in CC and BHD tumors. The first and second groups represent those gene sets from MsigDB that are unique to CC and BHD, respectively, as compared to the other RCC subtypes given in Figure 1A. The third group is a comparison of the BHD tumor gene expression data with only CH and ON gene expression data. B) The most differentially expressed gene set in CC tumor samples compared to the other RCC subtypes. C) The most differentially expressed gene set in BHDS tumor samples compared to the other RCC subtypes. D) Heatmap of enrichment scores for the thirty most differentially expressed gene sets in BHD versus CH and ON. On the left is a dendrogram displaying the calculated pairwise distances between dissimilarities of gene set compositions. E) The most differentially expressed gene set in BHD tumors as compared with CH and ON. Note that enrichment values for the other RCC subtypes are given here for reference in B, C, and E.
Klomp et al. BMC Medical Genomics 2010 3:59 doi:10.1186/1755-8794-3-59