Open Access Research article

Birt-Hogg-Dubé renal tumors are genetically distinct from other renal neoplasias and are associated with up-regulation of mitochondrial gene expression

Jeff A Klomp1, David Petillo2, Natalie M Niemi3, Karl J Dykema1, Jindong Chen2, Ximing J Yang4, Annika Sääf5, Peter Zickert6, Markus Aly7, Ulf Bergerheim8, Magnus Nordenskjöld5, Sophie Gad9, Sophie Giraud1011, Yves Denoux12, Laurent Yonneau13, Arnaud Méjean1114, Viorel Vasiliu1115, Stéphane Richard9, Jeffrey P MacKeigan3, Bin T Teh162 and Kyle A Furge12*

Author Affiliations

1 Laboratory of Computational Biology, Van Andel Research Institute, Grand Rapids, MI, USA

2 Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, MI, USA

3 Laboratory of Systems Biology, Van Andel Research Institute, Grand Rapids, MI, USA

4 Division of Surgical Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

5 Department of Molecular Medicine and Surgery and Center for Molecular Medicine, Karolinska Institutet at Karolinska University Hospital, SE-171 76 Stockholm, Sweden

6 Department of Pathology, Karolinska University Hospital, SE-182 88 Stockholm, Sweden

7 Division of Urology, Department of Clinical Sciences, Karolinska Institutet at Danderyd Hospital, SE-182 88 Stockholm, Sweden

8 Department of Surgery, Karolinska Institutet at Danderyd Hospital, SE-182 88 Stockholm, Sweden

9 Génétique Oncologique EPHE, INSERM U753, Le Kremlin-Bicêtre and Institut Gustave Roussy, Villejuif, France

10 Laboratoire de Génétique, Hôpital Edouard Herriot, Hospices Civils, Lyon, France

11 Centre de Références Cancers Rares PREDIR de l'INCa, Service d'Urologie, AP-HP, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France

12 Laboratoire d'Anatomie Pathologique, Hôpital Foch, Suresnes, France

13 Service d'Urologie, Hôpital Foch, Suresnes, France

14 Service d'Urologie, Hôpital Necker, Paris, France

15 Laboratoire d'Anatomie Pathologique, Hôpital Necker, Paris, France

16 NCCS-VARI Translational Research Laboratory, National Cancer Centre of Singapore, Singapore

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BMC Medical Genomics 2010, 3:59  doi:10.1186/1755-8794-3-59

Published: 16 December 2010

Additional files

Additional file 1:

Supplementary Tables S1-S4. This file contains four supplementary tables: Table S1- characteristics of BHD-derived tumor samples, Table S2- top 200 genes differentially expressed between BHD renal tumors and sporadic renal oncocytomas (ON) and chromophobe RCC (CH) samples, Table S3- most significantly enriched gene sets in BHDS-derived tumor samples versus sporadic oncocytoma (ON) and chromophobe RCC (CH) samples, and Table S4- primer and probe sequences for qRT-PCR validation of genes in BHDS, CH, ON, and CC tumors relative to Normal kidney.

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Additional file 2:

Supplementary Figures S1-S3. This file contains three supplementary figures: Figure S1- gene expression measurements for individual genes deregulated in BHDS tumors, Figure S2- heatmap of differentially expressed genes from Figure 1E in sporadic kidney tumors, and Figure S3- histological images of sample BHD4.

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