The summarization of gene expressions grouped on physical locations of genomic cytobands, relative to normal samples from bladder. bNO: normal samples from bladder; rNO: normal samples from renal pelvis; bUC: bladder UC; rUC: renal pelvis UC. A) Unsupervised clustering result of the samples using raw summarization data. The majority of tumor and normal samples are separated, while the rUCs and bUCs are mixed with each other, showing indistinguishable summarization profiles. B) The summarization plot reflects underlying genomic imbalances in our study population and correctly identifies the most frequently observed cytogenetic alterations previously documented in UC (marked on right margin of the plot).
Zhang et al. BMC Medical Genomics 2010 3:58 doi:10.1186/1755-8794-3-58