Table 2

Significantly up- and down-regulated genes that discriminate resistant (R) from sensitive (S) CLL patients and that are common to males (M) and females (F)

Gene name*

Gene Symbol

Chromosome Location

Fold change RM vs. SM

Fold change RF vs. SF


trafficking protein, kinesin binding 2

TRAK2

2q33

0.054

0.379

calcium channel, voltage-dependent, P/Q type, alpha 1A subunit

CACNA1A

19p13.2-p13.1

0.116

0.135

contactin associated protein-like 2

CNTNAP2

7q35-q36

0.003

0.060

C-terminal binding protein 1

CTBP1

4p16

0.290

2.344

discs, large (Drosophila) homolog-associated protein 4

DLGAP4

20q11.23

0.164

0.389

DNA polymerase-transactivated protein 6

DNAPTP6

2q33.1

0.199

0.177

developmentally regulated GTP binding protein 2

DRG2

17p11.2

0.320

0.442

G protein pathway suppressor 2

GPS2

17p13

0.430

0.425

HOM-TES-103 tumor antigen-like

HOM-TES-103

12p13.3

0.303

0.446

integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)

ITGAE

17p13

0.450

0.434

phosphoribosylformylglycinamidine synthase (FGAR amidotransferase)

PFAS

17p13.1

0.320

0.457

pleckstrin homology domain containing, family B (evectins) member 1

PLEKHB1

11q13.5-q14.1

0.203

0.484

RNA binding motif, single stranded interacting protein 1

RBMS1

2q24.2

0.036

0.352

v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3

RELB

19q13.31-q13.32

0.245

3.033

transmembrane protein 33

TMEM33

4p13

0.203

2.013

vesicle-associated membrane protein1, synaptobrevin1

VAMP1

12p

0.287

0.395

vanin 2

VNN2

6q23-q24

0.434

0.424


*Genes listed were identified as being differentially expressed after direct comparisons of gene expression profiles between resistant and sensitive CLL samples for males and females. FC, fold change

Marteau et al. BMC Medical Genomics 2010 3:53   doi:10.1186/1755-8794-3-53

Open Data