Open Access Research article

Concomitant heterochromatinisation and down-regulation of gene expression unveils epigenetic silencing of RELB in an aggressive subset of chronic lymphocytic leukemia in males

Jean-Brice Marteau1, Odile Rigaud1, Thibaut Brugat1,5,6, Nathalie Gault1, Laurent Vallat2, Mogens Kruhoffer3, Torben F Orntoft3, Florence Nguyen-Khac2, Sylvie Chevillard4, Hélène Merle-Beral2 and Jozo Delic1,4*

1 Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA) Direction des Sciences du Vivant (DSV) Institut de Radiobiologie Cellulaire et Moléculaire (IRCM), Laboratoire d’Onco-Hématologie (LOH), France

2 GH Pitié Salpêtrière, Service d’Hématologie Biologique, AP-HP, Université Paris 6, Inserm U543, 47, Bd de l’Hôpital, Paris (75013), France

3 University of Aarhus, Department of Clinical Biochemistry, Brendstrupgaardsvej 100, Aarhus DK-8200, Denmark

4 Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA) Direction des Sciences du Vivant (DSV) Institut de Radiobiologie Cellulaire et Moléculaire (IRCM), Laboratoire de Cancérologie Expérimentale (LCE), 18, Av du Panorama, Fontenay-aux-Roses (92265), France

5 Université René Descartes-Paris V, 4, Av de l'Observatoire, Paris (75006), France

6 Current Address: Jean Langhorne's Lab, Division of Parasitology, National Institute for Medical Research, The Ridgeway London, NW71AA, UK

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BMC Medical Genomics 2010, 3:53 doi:10.1186/1755-8794-3-53

Published: 10 November 2010

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