Table 1

Differential expression of angiogenesis-related genes in DS vs C endothelial progenitors

Gene name

Gene symbol

RefSeq

Fold change

Function


Chemokine (C-X-C motif) ligand 10

CXCL10

NM_001565

6.7 I

Antiangiogenic chemokine


Interferon stimulated gene 20

ISG20

NM_002201

4.4 I

Angiogenesis inhibitor


SAM domain- and HD domain-containing protein 1

SAMHD1

NM_015474

3.0 I

INTERFERON-γ STIMULATED; ANGIOGENESIS INHIBITOR


Caspase 8

CASP8

NM_001228

3.5 D

Adhesion and homing of EPC


Chemokine (C-X-C motif) ligand 12

CXCL12

NM_199168

10.2 D; 5.7 D

Mobilization and recruitment of EPCs


Chemokine (C-X-C motif) receptor 4

CXCR4

NM_001008540

3.0 D

Endothelial cells migration and homing


Chemokine (C-X-C motif) receptor 7

CXCR7

NM_020311

4.3 D

Endothelial cells migration and homing


Endothelin 1

EDN1

NM_001955

13.6 D; 3.5 D

Promotes migration and proliferation of endothelial cells


Endothelin receptor type B

EDNRB

NM_000115

2.8 D

Migration, proliferation of endothelial cells


Vascular endothelial growth factor A

VEGFA

NM_001025367

3.6 D

Angioproliferative


Stanniocalcin 1

STC1

NM_003155

56.0 D

VEGF-mediated angiogenic response


Costa et al. BMC Medical Genomics 2010 3:40   doi:10.1186/1755-8794-3-40

Open Data