Table 1

Significantly differentially regulated pathways.

Rank

Pathway

Differentially regulated

Number of reactions

Down-regulated in unfavorable

Up-regulated in unfavorable

P-value


1

Histidine metabolism

6

14

3

3

1.15E-05

2

Alanine and aspartate metabolism

8

19

2

6

1.56E-05

3

Valine, leucine and isoleucine degradation

13

36

10

3

3.74E-05

4

Pyrimidine metabolism

37

75

3

34

2.25E-04

5

Fatty acid metabolism

14

36

9

5

2.48E-04

6

Biosynthesis of Steroids

10

41

2

8

3.12E-04

7

Methionine metaboplism

4

12

2

2

7.36E-04

8

Purine metabolism

17

91

3

14

1.21E-03

9

Glycine, Serine and Threonine metabolism

12

31

4

8

1.28E-03

10

Propanoate metabolism

4

18

3

1

2.12E-03

11

Lysine Biosynthesis

6

6

5

1

2.33E-03

12

Aminoacyl-tRNA biosynthesis

5

20

1

4

2.83E-03

13

Glycolysis/Gluconeogenesis

17

32

1

16

3.85E-03

14

Bile acid biosynthesis

10

28

4

6

5.26E-03

15

Pentose phosphate pathway

5

20

1

4

8.84E-03

16

Inositol phosphate metabolism

8

25

1

7

9.75E-03

17

Pyruvate metabolism

6

27

2

4

1.20E-02

18

Fructose and mannose metabolism

11

23

1

10

1.55E-02

19

Galactose metabolism

8

24

4

4

2.00E-02


Pathways with significant regulation patterns and more than three differentially regulated reactions (as defined by KEGG), bold: pathways which had also significant patterns in the second analyzed dataset.

Schramm et al. BMC Medical Genomics 2010 3:39   doi:10.1186/1755-8794-3-39

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